Cell damage shifts the microRNA content of small extracellular vesicles into a Toll-like receptor 7-activating cargo capable to propagate inflammation and immunity

Abstract Background The physiological relevance of cell-to-cell communication mediated by small extracellular vesicle-encapsulated microRNAs (sEV-miRNAs) remains debated because of the limiting representativity of specific miRNAs within the extracellular pool.We hypothesize that sEV-miRNA non-canonical function consisting of the stimulation of Toll

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Development and Assessment of a Point-of-Care Application (Genomic Medicine Guidance) for Heritable Thoracic Aortic Disease

Abstract BackgroundGenetic testing can determine familial and personal risks for heritable thoracic aortic aneurysms and dissections (TAD).The 2022 American College of Cardiology/American Heart Association guidelines for TAD recommend management decisions based on the specific gene mutation.However, many clinicians lack sufficient comfort or insigh

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Personalized information system for the control of tuberculosis in resource-limited settings: A simplistic proposal approach

Passive case finding remains the mainstay of tuberculosis (TB) control in several resource-limited countries.Although TB prevalence and mortality rates have declined in recent years, an estimated 3 million cases a year still go undetected and/or unreported, and delays in the diagnosis and treatment of TB continue to be widespread.It has been shown

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